![]() During appropriate use of acetaminophen at therapeutic doses, the small amount of NAPQI produced is readily detoxified by intracellular glutathione. In addition to these pathways, approximately 5% of an acetaminophen dose is metabolized by cytochrome P450 enzymes (mainly CYP2E1), which results in the formation of a highly reactive metabolite, N-acetyl-p-benzoquinone imine (NAPQI). Oxidative metabolism: At therapeutic doses, 95% of APAP is metabolized via glucuronidation and sulfation in the liver and eliminated from the body without resulting toxicity. Acetaminophen overdose can induce acute liver failure by a process that involves two processes: oxidative metabolism and amplification of oxidant stress. This is a persistent health problem because acetaminophen is widely available in the US market. Acetaminophen overdose is the most common cause of drug-induced acute liver failure (ALF) in the US, accounting for 46% of all cases, which results in about 300-500 deaths annually. ![]() ![]() Unintentional and intentional overdoses occur and can cause serious hepatotoxicity. The maximal recommended therapeutic dose of 4 g per day is safe and is well tolerated. Why Should I Register and Submit Results?Īcetaminophen (N-acetyl-p-aminophenol, paracetamol) is a commonly used analgesic and antipyretic. ![]()
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