![]() ![]() The higher the INR means the thinner the blood is patient with artificial heart valve is given paradaxa. is taking warfarin/coumadin, nurse reviews labs and sees his pt is 40 and INR is 5.2 - patient at risk bleeding Low dose aspirin once daily for prophylaxis, higher doses for acute eventsĪdverse effects: bleeding risk, GI upset (aspirin)ĭrug interactions: anticoagulants these prototype drugs for coagulation are given orally aspirin, clopidogrel, warfarin, dabigatran effects of heparin and lovenox can be reversed with this drug protamine sulfate this oral anticoagulant is highly protein bound, leading to a multitude of warfarin and drug interactions these two anticoagulants may cause gI distress warfarin/coumadin and dabigatran/pradaxa a patient with a low albumin level will be at a higher risk for bleeding and heparin or warfarin vitamin K is the antidote for coumadin, so need to watch Vitamin K rich foods.Īvocadoes, broccoli, green apples, green grapes, (look up more) leafy greens, cucmbers, onion, tomatoes Patient with A Fib. No metabolic drug interactions Aspirin & PLavix (clopidrogel) ![]() No metabolic drug interactions How to monitor for bleeding? ("please don't flush", look at stool and urine) blood in vomit looks like coffee grounds, smells very bad warfarin (Coumadin)ĭrug interactions - pharmacodynamics manyĪcetaminophen, cimetidine Pradaxa (dabigatran) ![]() Renal Elimination (so worry about kidneys- labs for kidneys - creatinine, _, _)Īdv eff: bleeding, hemorhhage, GI irritation Increase bleeding risk also using: glucocorticoids, anti platelet drugs (aspirin),ĭecreased effectiveness with: oral contraceptives, foods high in vitamin K(leafy greens)Īcetaminophen, cimetidine pradaxa/dabagitran : bleeding, hemorrhage, GI irritation (upset stomach, ulceration) 99% protein bound - lab monitoring (PT/INR)Īdv eff. ![]()
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